Background and aim: Assessment of scientific outputs is necessary. This paper studied Royan Institute’s research outputs in Web of Science from 1997 to 2014.

Material and methods: Data were collected from Web of Science database using Scientometrics methods. Data received, analyzed using Excel 2010 and Bibexcel, and data visualized using VOSviewer.

Findings: Royan Institute had 892 documents in total, which was about half percent of scientific documents in country in 2014 and the average of annual growth rate has been about 43%. Three areas of gynecology, reproductive biology and cell biology research constituted the main research topics of Royan. Hirsch index of the Institute was 37 and 40% of its scientific documents published in Q1 and Q2 Journals. Average citation to each article of international collaboration, national collaboration and non-collaboration papers was 14, 6, and 4, respectively.

Conclusion: The Royan Institute is one of the main Institutes in the field of medical research and its output growth rate was higher than that of Iran. Evaluation of quality indicators showed the relative quality of scientific outputs and collaborative papers of this Institute had higher quality in terms of citation impact.